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Lung Cancer: A successful transplantation of an artificial bronchus

If the tumor is located in the periphery of the lung, only a portion of the lung is removed. But if the tumor is more central, complete removal may be necessary
If the tumor is located in the periphery of the lung, only a portion of the lung is removed. But if the tumor is more central, complete removal may be necessary
 

The team of Professor Emmanuel Martinod successfully transplanted artificial bronchus in a78 year patient with cancer, saving him the complete removal of the lung. This innovative surgery, performed October 28, 2009, is meant not only to remove the cancerous lesion with greater safety margins, but also to avoid the complete removal of lung which involvs high mortality risk.

The patient "is fine", told AFP Professor Emmanuel Martinod, thoracic and vascular surgeon, who performed the surgery. "He needs regular monitoring, but he goes well, he walks, he goes into his country house." Currently, surgery is the best treatment for early forms of non-metastatic lung cancer, the deadliest of cancers.

If the tumor is located in the periphery of the lung, only a portion of the lung is removed. But if the tumor is more central, complete removal may be necessary. The postoperative mortality is now higher, up to 26% at 90 days. "Even if you can live with one lung, removal of the lung is the most risky procedure of all surgeries together," said Professor Martinod.

The bronchus is composed of artificial biological tissue (aortic tissue) reinforced by a steel structure house (stent). The aortic tissue graft, preserved by cold and stored in tissue banks, already used in vascular surgery, has the advantage of not requiring anti-rejection drugs. Aortic tissue is a "matrix" that are colonizing with the bronchial cells to reconstitute an epithelium with ciliated cells.

The experimental work was conducted in the research laboratory of Professor Alain Carpentier, known worldwide for the development of bioprosthetic heart valves. A study of 20 to 30 patients due to start this month to confirm this first result.

 
 
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