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Researchers managed prevent the aging process in mice

Researchers managed to rid the body of mice of old cells which accumulate with age
Researchers managed to rid the body of mice of old cells which accumulate with age

American scientists have managed to prevent the aging process. In a few years perhaps, these technologies will be commonplace.

Research on aging explode in the laboratories of research around the world. For this week, three or four high-level international scientific press publications provide strong arguments to show that experimentally it is possible to reverse the effects of aging, at the cell level of course, but also at the level of a complete individual. These searches are currently experimental and complex, but they aim to prove that fight aging is possible.

In a few years, perhaps, technologies or anti-aging drugs which seem to us impossible or futuristic today, as were the organ transplantation and fertilization in vitro early last century, will be commonplace.

Mayo Clinic scientists (Minnesota, United States), led by Jan van Deursen, reveal that they have managed to rid the body of mice of old cells which accumulate with age. They believe that this will delay or prevent the arrival of ailments associated with aging and to extend the healthy life years.

Their work, published in the British scientific journal Nature, focuses on a genetically modified mouse model. They demonstrate for the first time that if it manages to eliminate the senescent cells of the body, it remains in better overall. Cells having reached the state of senescence cease to be divided into new cells, but indeed produce substances that damage surrounding cells and cause inflammation of the tissues. Senescent cells represent more than 10 to 15% of all of the cells of the very elderly. The immune system regularly removes these cells but is overwhelmed with time. At the time, they cease to accumulate.

Researchers have created transgenic mice, which senescent cells contain an enzyme caspase-8. Once the mouse is exposed to the drug, the enzyme specifically induced death of senescent cells. Researchers have observed that the elimination of the only senescent cells during the life of rodents delayed disorders related to age, such as cataracts, muscle melt or thinning of the skin, signs of normal aging.

They also could see that the destruction of these cells including later in life could also slow the progression of already existing disorders. "By attacking these cells and their products, we can perhaps someday break the link between the processes of aging and susceptibility to diseases, like heart disease, stroke, cancers or dementia", James Kirkland, co-author of the study says.


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